Endocrine Abstracts

Background and aims: Dehydroepiandrosterone fatty acid esters (DHEA-FAEs) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives with long-lasting hormonal activity. DHEA-FAEs function through hydrolysis of DHEA-FAEs into free DHEA and further metabolized to biologically active steroids. The lysosomal acid lipase (LAL) mediates the intracellular hydrolysis of cholesterol esters. This study aims to study the possible role of LAL on the hydrolys...

Background and aims: Dehydroepiandrosterone (DHEA) is an important prohormone and precursor of all sex steroids. DHEA fatty acid esters (DHEA-FAEs) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives with long-lasting hormonal activity, which are exclusively transported in lipoproteins. In the circulation, DHEA is esterified in a reaction catalyzed by lecithin-cholesterol acyltransferase associated with HDL particles. The physiological role...

Objective: The tumor suppressor gene methylation lead to gene silencing, it plays an important role in thyroid tumor occurrence and development. This study examined the tumor suppressor gene (PTEN, RASSF1A, DAPK, RARβ2) DNA methylation and mRNA expression status in the peripheral blood of patients with nodular thyroid disease. Discuss its clinical significance. For the benign and malignant thyroid nodules early identification of molecular diagnosis is based.<p class="...

Purpose: Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the effect of apatinib and the combination therapy with radioactive iodine (RAI) in patients with progressive metastatic DTC.Methods: Five patients (all female mean age 62 &pm; 8 years, ranged from 51 to 69 years) with progressive distant metastatic DTC (dmDTC) after t...